奈米工程與微系統研究所　書報討論

Seminar of Inst. NanoEngineering and MicroSystems

Speech I. Tang-Long Shen

National Taiwan University

Department of Plant Pathology and Microbiology Professor

Title: Discovery and Utility of Biomarkers in Liquid Biopsy for Early Detection of Breast Cancer.

Abstract

In an era of precision medicine, biomarker discovery is indispensable for early detection, therapeutic efficacy monitoring, and outcome prediction. MicroRNAs within patient serum exosome have emerged as significantly measurable biomarkers, which abundantly existed in the form of liquid biopsies, for several diseases, including cancers. They are essential regulators of global mRNA expression in cells. Aberrant regulation of miRNA can enables resulting in tumor initiation, drug resistance and metastasis in cancer. miRNA assays are convenient for large-scale studies covering multiple miRNA targets and realistic in screening across diverse breast cancer types for early detection or factors that drive cancer progression.

Through identifying these heterogeneous compositions of the cancer cells, understanding of the molecular mechanisms underlying these identified biomarkers, which is essential in developing effective treatments and translational research, could be established.

Brief Biography

1987-1991, B.S., National Taiwan University, Department of Plant Pathology and Entomology, Taipei, Taiwan.

1992-1994, M.S., National Taiwan University, Institute of Plant Pathology, Taipei, Taiwan.

1997-2002, Ph.D., Cornell University, Department of Molecular Medicine, USA.

15:30-17:20 on May 20th(Mon), 2019 at Room 108 of Eng. Building I

Host：Prof. J.Andrew Yeh jayeh@mx.nthu.edu.tw Ext:42912

Contact：Yu-Chen Lin(RA) s8317947@gmail.com