奈米工程與微系統研究所　書報討論

Seminar of Inst. NanoEngineering and MicroSystems

胡尚秀 副教授

國立清華大學 醫環系

Prof. Shang-Hsiu Hu,

Department of Biomedical Engineering and Environmental Science,

National Tsing Hua University

E-mail: shhu@mx.nthu.edu.tw

Targeted Delivery of Multiple component Cargos to Cancer Cells by Core/shell Nanocapsules

Abstract

Delivery of drug and energy within responsive carriers that effectively target and accumulate in cancer cells promise to mitigate side effects and to enhance the uniquely therapeutic efficacy demanded for personalized medicine. To achieve this goal, however, these carriers which are usually piled up at the tumors periphery near the blood vessels must simultaneously overcome the challenges in low tumor penetration and transport sufficient cargos to the deep tumor to eradicate whole cancer cells. Here, we report a sponge-like carbon material on graphene nanosheet (graphene nanosponge)-supported lipid bilayers (lipo-GNS) that doubles as a photothermal agent and high cargo payload platform, which releases a burst of drug/energy (docetaxel (DTX) and gasified perfluorohexane (PFH)) and intense heat upon near-infrared irradiation. Ultrasmall lipo-GNS (40 nm) modified with a tumor targeting protein that penetrates the tumor spheroids through transcytosis exhibited a 200-fold increase in accumulation than a 270 nm variant of the lipo-GNS. Furthermore, a combination of therapeutic agents (DTX and PFH) delivered by lipo-GNS deep into tumors was gasified and released into the tumor spheroids, and successfully ruptured and suppressed xenograft tumors in 16 days without distal harm when subjected to a single 10 min near infrared (NIR) laser treatment.

2018年11月19日(週一)，1530－1720，工程一館108室

15:30-17:20 on Nov. 19 (Mon), 2018 in Room 108 of Eng. Building I

Host：Prof. Da-Jeng Yao  djyao@mx.nthu.edu.tw Ext: 42850

Contact：黃微稜 hwleng@mx.nthu.edu.tw  Ext: 33737

TA：李志恩 c27180339@gmail.com